2026 Publications
A novel directed evolution platform for engineering chemically gated protein switches
Chem Communc (Camb)
March 17, 2026
Vázquez-Rivera LA, Shen J, Shingles G, Zhou G, Wang W.
J Am Chem Soc
February 24, 2026
Hungerford J, Mydy LS, Wang X, Mendoza-Perez L, Ousley DA, Shafiq K, McDonough KM, Li W, May G, Chigumba DN, Yao S, Kersten RD.
Insights into the structure and modulation of human TWIK-2
Nat Commun
January 31, 2026
Ma Q, Hernandez CC, Navratna V, Kumar A, Rana JK, Zong J, Lee A, Mosalaganti S
bioRxiv [Preprint]
January 22, 2026
Abernathy M, Aboulhosn K, Ohmer C, Ragsdale S, Sarangi R.
A chemogenetic approach for temporal and cell-specific activation of endogenous GPCRs in vivo
Proc Natl Acad Sci USA
January 13, 2026
Shingles G, Pang Q, Weng J, Singer R, Babar W, Shen J, Vazquez-Rivera L, Chen Y, Li P, Wang W.
Environ Toxicol
January 10, 2026
Hart LN, Lev KL, Hefferan S, Premathilaka SH, Thenuwara SI, Isailovic D, Sherman DH, Dick GJ.
2025 Publications
Commun Chem
December 5, 2025
McBride CM, McCauley M, Harris NR, Amin S, Curtis BJ, Verhey-Henke L, Teklemichael AA, Oliphant EN, Dranchak P, Lev KL, Qu F, Snodgrass HM, Lewis JC, Inglese J, Su XZ, Pereira F, Sherman DH.
Synthesis of enantioenriched atropisomers by biocatalytic deracemization
Nature
November 12, 2025
Casandra P. Sandoval Hurtado, Ronnie Rios, Kasandra Negrete, Stephany Mendez-Ortega, Richard Nun
CTE-Type Tau Filaments in Alzheimer's Disease with Co-morbid LATE-NC
bioRxiv [Preprint]
October 22, 2025
Rana JK, Pinarbasi ES, Fernandez MG, Navratna V, Conway KS, Lieberman AP, Barmada SJ, Mosalaganti S.
Programmable conjugative CRISPR interference targeting genotoxin in the gut
bioRxiv [Preprint]
Octber 14, 2025
Hamp B, Timek H, Fang C, Wang Z, Haley AE, Jennings M, Chimezie CI, Hutchinson N, Dong Z, McCollum S, Khawaled S, Shah YM, Yilmaz O, Li J.
In situ cryo-ET redefines HPV disassembly and transport paradigms
bioRxiv [Preprint]
Sutanto R, Rana J, Tsai B, Mosalaganti S
Redefining the role of the EryM acetyltransferase in natural product biosynthetic pathways
Structure
August 7, 2025
Li Y, Liu X, Harris NR, Roberts JR, Valdivia EM, Ji X, Smith JL.
CRISPR RiPCA for Investigating eIF4E-m7GpppX Capped mRNA Interactions
ACS Chemical Biology
August 6, 2025
Vega-Hernández G, Duque J, Klein BJC, Soueid DM, Rech JC, Wang H, Zhou W, Garner AL.
J Am Chem Soc
July 23, 2025
Smith KL, Arbuckle MA, Kim AT, Tsai CY, McIntosh JA, Verma D, Shim E, Narayan ARH.
A Molecular Tricopper Phosphide: Synthesis, Functionalization, and Hydrogen Atom Abstraction
J AM Chem Soc
June 30, 2025
Beamer AW, Aboulhosn K, Buss JA.
Engineering a Biosynthetic Pathway to Produce (+)-Brevianamides A and B
ACS Catalysis
April 10, 2025
Casandra P. Sandoval Hurtado; Samantha P. Kelly; Vikram V. Shende; Makayla Perez; Brian J. Curtis; Sean A. Newmister; Kaleb Ott; Filipa Pereira; David H. Sherman
ACS Chem Neurosci
April 2, 2025
Veire JL, Lucas MJ, Bond LG, Tripu DR, Tessier PM, Greineder CF.
Optimized production of concanamycins using a rational metabolic engineering strategy
Metab Eng
March 14, 2025
Pereira F, McCauley M, Lev K, Verhey-Henke L, Condren AR, Harte RJ, Galvez J, Sherman DH.
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Nucleic Acids Res
January 6, 2025
Mitja M Zdouc et al., (Includes Lev K)
2024 Publications
ACS Med Chem Lett
Dec 12 2024
Cárdenas EL, O'Rourke RL, Menon A, Vega-Hernández G, Meagher J, Stuckey J, Garner AL.
bioRxiv [Preprint]
November 25, 2024
Reuter MM, Lev KL, Albo J, Arora HS, Liu N, Tan S, Shay MR, Sarkar D, Robida A, Sherman DH, Richardson RJ, Cira NJ, Chandrasekaran S.
Methods Enzymol
October 29, 2024
Aboulhosn K, Ragsdale SW
Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)
Elife
August 28, 2024
Navratna V, Kumar A, Rana JK, Mosalaganti S.
Nature-Inspired Radical Pyridoxal-Mediated C-C Bond Formation
J Am Chem Soc
August 21 ,2024
Wang Y, Das S, Aboulhosn K, Champagne SE, Gemmel PM, Skinner KC, Ragsdale SW, Zimmerman PM, Narayan ARH
Gastro Hep Adv
August 12, 2024
Meyer SR, Zhang CJ, Garcia MA, Procario MC, Yoo S, Jolly AL, Kim S, Kim J, Baek K, Kersten RD, Fontana RJ, Sexton JZ.
Life Sci Alliance
June 26, 2024
Navratna V, Kumar A, Rana JK, Mosalaganti S
2023 Publications
Targeting Dalbavancin Inoculum Effect: Adjunctive Single Dose of Daptomycin
Infect Dis Ther
October 12, 2023
Kebriaei R, Abdul-Mutakabbir JC, Stamper KC, Lev KL, Rybak MJ.
2022 Publications
J Lipid Res
June 23, 2022
Taslima Gani Khan, David Ginsburg, Brian T Emmer
Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
PLoS Comput Biol
April 1, 2022
Amanda L Peiffer, Julie M Garlick, Stephen T Joy, Anna K Mapp, Charles L Brooks 3rd
Purification and structural elucidation of a cobalamin-dependent radical SAM enzyme
Methods Enzymol
February 22, 2022
Zerick Dill, Bin Li, Jennifer Bridwell-Rabb
Targeting allosteric regulation of cancer metabolism
Nat Chem Biol
May 1, 2022
Daniel M Kremer, Costas A Lyssiotis
The Transformative Power of Biocatalysis in Convergent Synthesis
J Am Chem Soc
March 30, 2022
Lara E Zetzsche, Suman Chakrabarty, Alison R H Narayan
Microbiology
April 1, 2022
Aathmaja Anandhi Rangarajan, Hannah E Chia, Christopher A Azaldegui, Monica H Olszewsk, Gabriel V Pereira, Nicole M Koropatkin, Julie S Biteen
Biocatalytic oxidative cross-coupling reactions for biaryl bond formation
Nature
March 1, 2022
Lara E Zetzsche, Jessica A Yazarians, Suman Chakrabarty, Meagan E Hinze, Lauren A M Murray, April L Lukowski, Leo A Joyce, Alison R H Narayan
Chemical modifications to mRNA nucleobases impact translation elongation and termination
Biophys Chem
June 1, 2022
Monika K Franco, Kristin S Koutmou
Elife
March 7, 2022
Ali A Kermani*, Olive E Burata*, B Ben Koff, Akiko Koide, Shohei Koide, Randy B Stockbridge
ACS Chem Biol
May 20, 2022
Yongtong Lao, Meredith A Skiba, Stephanie W Chun, Alison R H Narayan, Janet L Smith
Proc Natl Acad Sci USA
January 25, 2022
Meredith K Purchal, Daniel E Eyler, Mehmet Tardu, Monika K Franco, Megan M Korn, Taslima Khan, Ryan McNassor, Rachel Giles, Katherine Lev, Hari Sharma, Jeremy Monroe, Leena Mallik, Markos Koutmos, Kristin S Koutmou
2021 Publications
New Orange Ligand-Dependent Fluorescent Reporter for Anaerobic Imaging
ACS Chem Biol
November 19, 2021
Hannah E Chia, Karl J Koebke, Aathmaja A Rangarajan, Nicole M Koropatkin, E Neil G Marsh, Julie S Biteen
A Dual-Site Inhibitor of CBP/p300 KIX is a Selective and Effective Modulator of Myb
J Am Chem Soc
September 22, 2021
Stephen T Joy, Matthew J Henley, Samantha N De Salle, Matthew S Beyersdorf, Isaac W Vock, Allison J L Huldin, Anna K Mapp
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
Nat Commun
August 11, 2021
Daniel M Kremer, Barbara S Nelson, Lin Lin, Emily L Yarosz, Christopher J Halbrook, Samuel A Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W Hou, Eileen S Carpenter, Anthony C Andren, Zeribe C Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E Mbah, Mengrou Shan, Nupur K Das, Brian Magnuson, Andrew C Little, Milan R Savani, Johanna Ramos, Tina Gao, Stephen A Sastra, Carmine F Palermo, Michael A Badgley, Li Zhang, John M Asara, Samuel K McBrayer, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Kenneth P Olive, Costas A Lyssiotis
Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites
Nat Struct Mol Biol
August 1, 2021
Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar
Molecular determinants for α-tubulin methylation by SETD2
J Biol Chem
July 1, 2021
Sarah Kearns, Frank M Mason, W Kimryn Rathmell, In Young Park, Cheryl Walker, Kristen J Verhey, Michael A Cianfrocco
Norstictic Acid Is a Selective Allosteric Transcriptional Regulator
J Am Chem Soc
June 30, 2021
Julie M Garlick, Steven M Sturlis, Paul A Bruno, Joel A Yates, Amanda L Peiffer, Yejun Liu, Laura Goo, LiWei Bao, Samantha N De Salle, Giselle Tamayo-Castillo, Charles L Brooks 3rd, Sofia D Merajver, Anna K Mapp
Discovery of Surfactins as Inhibitors of MicroRNA Processing Using Cat-ELCCA
ACS Med Chem Lett
April 2, 2021
Andrew W Robertson, Jorge Sandoval, Osama G Mohamed, Yihao Zhuang, Erin E Gallagher, Jennifer Schmidt, Lisa Caratelli, Arya Menon, Pamela J Schultz, Rachel M Torrez, Catherine L Hay, Bailey A Bell, Paul A Price, Amanda L Garner, Ashootosh Tripathi
Scribble sub-cellular localization modulates recruitment of YES1 to regulate YAP1 phosphorylation
Cell Chem Biol
March 11, 2021
Dongyu Zhao, Zhangyuan Yin, Matthew B Soellner, Brent R Martin
A live-cell assay for the detection of pre-microRNA-protein interactions
RSC Chem Biol
February 1, 2021
Sydney L Rosenblum, Daniel A Lorenz, Amanda L Garner
Genome-scale CRISPR screening for modifiers of cellular LDL uptake
PLoS Genet
January 29, 2021
Brian T Emmer, Emily J Sherman, Paul J Lascuna, Sarah E Graham, Cristen J Willer, David Ginsburg
2020 Publications
Covalent inhibition of NSD1 histone methyltransferase
Nat Chem Biol
December 1, 2020
Huang Huang, Christina A Howard, Sergei Zari, Hyo Je Cho, Shirish Shukla, Hao Li, Juliano Ndoj, Paula González-Alonso, Caroline Nikolaidis, Joshua Abbott, David S Rogawski, Mykhaylo A Potopnyk, Katarzyna Kempinska, Hongzhi Miao, Trupta Purohit, Andrew Henderson, Anna Mapp, Maria Luisa Sulis, Adolfo Ferrando, Jolanta Grembecka, Tomasz Cierpicki
The structural basis of promiscuity in small multidrug resistance transporters
Nat Commun
November 27, 2020
Ali A Kermani, Christian B Macdonald, Olive E Burata, B Ben Koff, Akiko Koide, Eric Denbaum, Shohei Koide, Randy B Stockbridge
Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles
J Biol Chem
November 23, 2020
Ameya P Jalihal, Andreas Schmidt, Guoming Gao, Saffron R Little, Sethuramasundaram Pitchiaya, Nils G Walter
Unexpected specificity within dynamic transcriptional protein-protein complexes
PNAS
October 19, 2020
Matthew J Henley, Brian M Linhares, Brittany S Morgan, Tomasz Cierpicki, Carol A Fierke, Anna K Mapp
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα
ACS Med Chem Lett.
October 8, 2020
James R Annand, Andrew R Henderson, Kyle S Cole, Aaron J Maurais, Jorge Becerra, Yejun Liu, Eranthie Weerapana, Angela N Koehler, Anna K Mapp, Corinna S Schindler
The Emergence of Phase Separation as an Organizing Principle in Bacteria
Biophys J
September 28, 2020
Christopher A Azaldegui, Anthony G Vecchiarelli, Julie S Biteen
Imaging living obligate anaerobic bacteria with bilin-binding fluorescent proteins
Curr Res Microb Sci
September 1, 2020
Hannah E Chia, Tiancheng Zuo, Nicole M Koropatkin, E Neil G Marsh, Julie S Biteen
Structure
August 4, 2020
Sarah Kearns
Bioessays
July 8, 2020
Scott E Campit, Alia Meliki, Neil A Youngson, Sriram Chandrasekaran
Broadening the scope of biocatalytic C-C bond formation
Nat Rev Chem
July 1, 2020
Lara E Zetzsche, Alison R H Narayan
Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases
Nat Commun
June 12, 2020
April L Lukowski, Jianxin Liu, Jennifer Bridwell-Rabb, Alison R H Narayan
Common biochemical properties of metabolic genes recurrently dysregulated in tumors
Cancer Metab
May 8, 2020
Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A Lyssiotis, Sriram Chandrasekaran
Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis
Nat Struct Mol Biol
April 20, 2020
Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR
Chembiochem
April 4, 2020
Fraley AE, Tran HT, Kelly SP, Newmister SA, Tripathi A, Kato H, Tsukamoto S, Du L, Li S, Williams RM, Sherman DH
FEBS Lett
April 1, 2020
Dylan C Mitchell, Arya Menon, Amanda L Garner
Protein Expr Purif
April 1, 2020
Tyler S Beyett, Qiuyan Chen, Emily J Labudde, Joseph Krampen, Prateek V Sharma, John J G Tesmer
Neurosci Lett
February 27, 2020
Denomme N, Lukowski AL, Hull JM, Jameson MB, Narayan ARH, Isom LL
Synthetic utility of one-pot chemoenzymatic reaction sequences
Synlett
February 1, 2020
Tyler J Doyon, Alison R H Narayan
Adipostatins E-J, New Potent Antimicrobials Identified as Inhibitors of Coenzyme-A Biosynthesis
Tetrahedron Lett
January 30, 2020
Lyanne Gómez-Rodríguez, Pamela J Schultz, Giselle Tamayo-Castillo, Garry D Dotson, David H Sherman, Ashootosh Tripathi
Structural biology of telomeres and telomerase
Cell Mol Life Sci
January 1, 2020
Smith EM, Pendlebury DF, Nandakumar
Following the messenger: Recent innovations in live cell single molecule fluorescence imaging
Wiley Interdiscip Rev RNA
January 1, 2020
Schmidt A, Gao G, Little SR, Jalihal AP, Walter NG
2019 Publications
FEBS Lett
December 18, 2019
Mitchell DC, Menon A, Garner AL
J Biol Chem
November 15, 2019
Emily J Sherman, Dylan C Mitchell, Amanda L Garner
Structural biology of telomeres and telomerase
Cell Mol Life Sci
November 14, 2019
Smith EM, Pendlebury DF, Nandakumar J
Pseudouridinylation of mRNA coding sequences alters translation
PNAS
October 31, 2019
Eyler DE, Franco MK, Batool Z, Wu MZ, Dubuke ML, Dobosz-Bartoszek M, Jones JD, Polikanov YS, Roy B, Koutmou KS
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe
PNAS
August 6, 2019
Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG
J Biol Chem
August 2, 2019
García-Torres D, Fierke CA
Extending fluorescence microscopy into anaerobic environments
Curr Opin Chem Biol
August 1, 2019
Chia HE, Marsh ENG, Biteen JS
Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
Nat Commun
June 3, 2019
Alexandrea N Rizo, JiaBei Lin, Stephanie N Gates, Eric Tse, Stephen M Bart, Laura M Castellano, Frank DiMaio, James Shorter, Daniel R Southworth
Natural Voltage-Gated Sodium Channel Ligands: Biosynthesis and Biology
Chembiochem
May 15, 2019
Lukowski AL, Narayan ARH
ACS Med Chem Lett
April 22, 2019
Amanda L Garner, Daniel A Lorenz, Jorge Sandoval, Erin E Gallagher, Samuel A Kerk, Tanpreet Kaur, Arya Menon
Cell Chemical Biology
April 8, 2019
Mitchell DC, Menon A, Garner AL
ACS Catal
April 5, 2019
Benítez AR, Tweedy S, Baker Dockrey SA, Lukowski AL, Wymore T, Khare D, Brooks CL 3rd, Palfey BA, Smith JL, Narayan ARH
Current Biology
March 13, 2019
Engelke MF, Waas B, Kearns SE, Suber A, Boss A, Allen BL, Verhey KJ.
Nat Protoc
February 14, 2019
Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM
2018 Publications
Whole-cell biocatalysis platform for gram-scale oxidative dearomatization of phenols
Chem Biol Drug Des.
November 28, 2018
Baker Dockrey SA, Doyon TJ, Perkins JC, Narayan ARH
Bioorg Med Chem
November 1, 2018
Tyler S Beyett, Xinmin Gan, Shannon M Reilly, Andrew V Gomez, Louise Chang, John J G Tesmer, Alan R Saltiel, Hollis D Showalter
Molecular Pharmacology
October 27, 2018
Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators
Proceedings of the National Academy of Science
September 20, 2018
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK6
GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode
ACS Chemical Biology
September 19, 2018
Cho HJ, Li H, Linhares BM, Kim E, Ndoj J, Miao H, Grembecka J, Cierpicki T
C-H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis
Journal of the American Chemical Society
September 19, 2018
Lukowski AL, Ellinwood DC, Hinze ME, DeLuca RJ, Du Bois J, Hall S, Narayan ARH.
Protein-protein interactions in "cis-AT" polyketide synthases
Natural Product Reports
September 6, 2018
Dodge GJ, Maloney FP, Smith JL
A Conditionally Fluorescent Peptide Reporter of Secondary Structure Modulation
Chembiochem
August 23, 2018
Garner AL, Johnson OT, Kaur T
ACS Medicinal Chemistry Letters
May 26, 2018
Lorenz DA, Kaur T, Kerk SA, Gallagher EE, Sandoval J, Garner AL
Biocatalytic site- and enantioselective oxidative dearomatization of phenols
Nature Chemistry
February 10, 2018
Baker Dockrey SA, Lukowski AL, Becker MR, Narayan ARH
2017 Publications
Dissecting the telomere-inner nuclear membrane interface formed in meiosis
Natural Structure & Molecular Biology
December 28, 2017
Pendlebury DF, Fujiwara Y, Tesmer VM, Smith EM, Shibuya H, Watanabe Y, Nandakumar J
High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions
ACS Combinatorial Science
December 11, 2017
Song JM, Menon A, Mitchell DC, Johnson OT, Garner AL
Profiling Protein S-Sulfination with Maleimide-Linked Probes
Chembiochem
October 18, 2017
Kuo YH, Konopko AM, Borotto NB, Majmudar JD, Haynes SE, Martin BR
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104
Science
July 24, 2017
Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR
Chemoselective ratiometric imaging of protein S-sulfenylation
Chemical Communications - Royal Society of Chemistry
June 19, 2017
Tom CTMB, Crellin JE, Motiwala HF, Stone MB, Davda D, Walker W, Kuo YH, Hernandez JL, Labby KJ, Gomez-Rodriguez L, Jenkins PM, Veatch SL, Martin BR.
2016 Publications
A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling
Angewandte Chemie
October 28, 2016
Bruno PA, Morriss-Andrews A, Henderson AR, Brooks CL 3rd, Mapp AK
Discovery of enzymatic targets of transcriptional activators via in vivo covalent chemical capture
Journal of the American Chemical Society
September 9, 2016
Dugan A, Majmudar CY, Pricer RE, Niessen S, Lancia JK, Fung HY, Cravatt BF, Mapp AK
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation
Nature Structural and Molecular Biology
August 1, 2016
Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR.